From the Bourne Bridge:

Follow Route 28 South to Falmouth. Approximately 13 miles from the bridge, you will pass through one set of traffic lights at Jones Road, approximately one half mile after the traffic lights take a left toward Falmouth center onto Palmer Ave. (still route 28), take your first right onto Hewins Way, the Inn will be directly in front of you at 51 Main Street. Parking is at the rear of the Inn off Siders Lane.

From Boston:

Take Route 24 South to I-495 South to the Bourne Bridge. Or take Route 3 South to the Sagamore Bridge Rotary, follow the signs to Buzzards Bay/Falmouth and cross the Bourne Bridge. See above for directions from the Bourne Bridge.

From Western Mass./ Connecticut / New York:

Take the Mass. Turnpike East to I-495 South to the Bourne Bridge. See directions from the Bourne Bridge (to the left). From Hyannis: Take Route 28 North to Falmouth, at the end of the center is the Falmouth Green, stay to the left of the Green and the Inn is the third house after St. Barnabas Memorial Church at 51 Main Street.